Increased Cancer Risk: Obesity is linked to an increased risk of developing various types of cancer, including breast, colorectal, ovarian, and pancreatic cancers.
Chronic Inflammation: The chronic inflammation associated with obesity contributes to cancer development by promoting DNA damage and cell proliferation.
Insulin Resistance: Obesity often leads to insulin resistance, and elevated insulin levels can stimulate cell growth, potentially increasing the risk of cancer.
Hormonal Imbalances: Adipose tissue in obese individuals produces hormones, such as estrogen, that can influence the development and progression of hormone-sensitive cancers.
Obesity-Related Pathways: Obesity affects signaling pathways related to cell survival, apoptosis, and immune response, all of which play roles in cancer development.
Impact on Immune Function: Obesity can impair the immune system's ability to detect and destroy cancer cells, potentially facilitating tumor growth.
Associations with Specific Cancers: The association between obesity and cancer risk may vary for different types of cancer, emphasizing the complex nature of these relationships.
Importance of Prevention: Addressing obesity through lifestyle modifications, including a healthy diet and regular physical activity, is considered a crucial aspect of cancer prevention.