Insulin Resistance: Obesity increases the risk of insulin resistance, which makes cells less receptive to insulin and leads to type 2 diabetes.
Obesity causes adipose tissue inflammation, which releases cytokines that cause insulin resistance and type 2 diabetes.
Obesity can cause excess fat storage, especially visceral fat, which releases free fatty acids. Free fatty acids increase insulin resistance.
Pancreatic beta cells, which create insulin, can malfunction due to obesity. Beta cells may struggle to meet insulin demand over time, raising blood sugar.
Due to insulin resistance, type 2 diabetes can cause hyperglycemia and weight gain. This increases fat accumulation.
The vicious loop between obesity and type 2 diabetes is obesity causes insulin resistance and diabetes causes weight increase.
Shared Risk Factors: Genetics, sedentary lifestyle, and poor diets link obesity and type 2 diabetes.
To increase insulin sensitivity and glycemic control, obesity and type 2 diabetes treatment frequently includes weight management, physical exercise, and food adjustments.